The intention of this study is to provide a holistic approach to interpretation of Berio’s Sequenza IV, illuminating some of the complexities and ambiguities of the score and offering possibilities for performance. Comparison of the original with the revised version of the score is shown to offer considerable insight upon performance decisions. Analytical observations are applied to the practical issues of interpretation and projection, such as the articulation of melody, phrasing, clusters and grace-notes. Consideration is given to stylistic issues, such as the appropriation of tonality and its implications for performance, and the use of time and rubato.